Gate physics Sample Papers

1. An antidiabetic drug Piogliazone used in Type 2 diabetes acts by
   (A) Decrease of glucose uptake in muscles (B) Increasing insulin sensitivity
   (C) Inhibiting intestinal n-glucosidase      (D) Stimulating insulin secretion
2. An angiotensin-II receptor blocker useful in treating hypertension is
   (A) Enalaprilat        (B) Valsartan         (C) Atenolol        (D) Amiodipine
   Co-administration of NSAIDs with Warfarin may often lead to
3.
   (A) Antagonistic interaction
   (B) Interaction to change in drug transport
   (C) Interaction due to disturbances in electrolyte balance
   (D) Additive or synergistic interaction
4. Laminaria and Kelp are the principal genera, currently used for the industrial
   production of
   (A) Carrageenans                             (B) Agar
   (C) Fucans                                   (D) Alginic acid and alginates
5. A transverse section of the root fo Glycyrrhiza glabra when treated with 80%
   sulphuric acid gave
   (A) Deep yellow colour                       (B) No reaction, but only charring
   (C) Deep blue colour                         (D) Deep red colour
6. Microscopy of the bulbs of Urginea Indica family Liliaceae shows
   (A) Prisms of calcium oxalate                (B) Calcium carbonate and silica
   (C) Rosettes of calcium oxalate              (D) Raphides of calcium oxalate
7. Streptomycin is a
   (A) di-acidic base possessing an aldehydic carbonyl group
   (B) tri-acidic base possessing an aldehydic carbonyl group
   (C) neutral compound possessing a ketonic group
   (D) acidic compound possessing a carboxylic group
8. The antihistamine with diphenyl methyl group is
   (A) Methdilazine                             (B) Cyclizine hydrochloride
   (C) Pheniramine                              (D) Phenindamine

9.  Heterocyclic rings present in pilocarpine are
    (A) Imidazole and Quinoline                     (B) Imidazole and Thiazole
    (C) Quinoline and Phenanthrene                  (D) Imidazole and Dihydrofuran
10. The most important microbial virulence factor in the etiology of bacterial
    meningitis is
    (A) Exotoxin                                    (B) Components of the capsule
    (C) Coagulase                                   (D) Hyaluronidase
11. Commonly used tetanus vaccine is produced by
    (A) treatment of the causative organism with heat or UV light and finally
    obtaining the toxoid
    (B) sub-culuring the virus at pH 10.4
    (C) artificially generating antibodies to viral glycoproteins
    (D) isolating the antigenicity genes from the causative organism
12. Which of the following equations is valid for standard B-DNA?
                                                    (C) 2(A+T)=3(G+C) (D) A+G=T+C
    (A) A+T=G+C              (B) A+T=2(G+C)
13. Clinical jaundice, typified by yellowing of the tissues is associated with elevated
    levels of
    (A) serum lysozyme                              (B) serum bilirubin
                                                    (D) serum γ-glutamyl transferase
    (C) serum creatinine
    In NMR spectrometry, the chemical shift ( δ ) is expressed in
14.
    (A) Parts per million (B) Gauss                 (C) Tesla             (D) Hertz
15. In chromatographic separation, the different species in the sample, undergo the
    process of
    (A) chemical interaction (B) partition          (C) volatilization    (D) ionization
16. A target material used in the production of X-rays is
    (A) potassium            (B) copper             (C) aluminium         (D) sodium
17. The requirements and guidelines for clinical trials, import and manufacture of
    new drugs as per the Drugs & Cosmetics Rules is given under Schedule
    (A)   N                  (B) Y                  (B) A                 (D) B
18. The growth of large particles at the expense of smaller ones, as a result of a
    difference in the solubility of the particles of varying sizes, is termed as
    (A)   Interfacial phenomenon                    (B) Partitioning
    (C)   Erosive formulation                       (D) Oswald ripening

19. Cyclic oligomers of glucose that form water soluble inclusion complexes, which
    are biocompatible and improve the bioavailability of drugs
    (A)   chlorophyll                             (B) polyethylene glycol
    (C)   cross povidone                          (D) cyclodextrin
20. 'Draves test' is associated with measuring the efficiency of
    (A) Detergents                                (B) Wetting agents
    (C)   Suspending agents                       (D) Adsorbent
                      Q. No. 21 – 75 Carry Two Marks Each
21. Effects of fibrates on blood lipids are mediated by
    (A) Inhibiting both synthesis and esterification of fatty acids
    (B) Their interaction with peroxisome proliferators-activated receptors (PPARs)
    (C) Reducing the conversion of HMG-CoA to mevalonate
    (D) Sequestering bile acids
22. A cardioselective beta blocker with vasodilating properties is
    (A) Pindolol            (B) Atenolol          (C) Bisoprolol     (D) Nebivolol

24. (-) – Hyoscyamine is
    (A) 15-20 times more active as a mydriatic than (+)- hyoscyamine
    (B) Inactive as a mydriatic
    (C) 3-5 times less active as a mydriatic than (+)- hyoscyamine
    (D) 100 times more active as a mydriatic than (+)- hyoscyamine

26. In thiazole diuretics, the position 7 is very important and is occupied by a
    (A) CH3 group                                  (B) Free sulphamoyl group
    (C) Chloro group                               (D) Free – NH2 group

28. A mass spectrum is obtained by plotting
    (A) Molecular weight versus peak height
    (B) Concentration versus peak height
    (C) Concentration versus degree of deflection of ions
    (D) Abundance of ions versus their m/e ratio
29. Aldehydes can be distinguished from other C=O containing compounds by IR,
    due to
    (A) The low frequency of absorption of aldehydes
    (B) The alkyl or aryl group is attached to >C=O
    (C) The double bond present
    (D) The double at the C-H-stretching region

30. A super disintegrant in tablet formulation is
    (A)   sodium starch glycollate                 (B) starch
    (C)   PVP                                      (D) Mg-Aluminium silicate
31. A drug was administered to 30 subjects as a tablet (30 mg), an oral aqueous
    solution (30 mg) and as an intravenous infusion (0.3 mg). Mean AUC's
    (ng.hr/mL), dose normalized to 1 mg, for tablet, oral solution and IV were 0.91,
    0.87 and 103.0 respectively.
    Calculate the relative bioavailability of the drug in tablet compared to the oral
    solution and the absolute bioavailability of tablet form
                                                   (B) 81%,5.6%
    (A)   104.6%, 0.883%
    (C)   10.46%, 8.83%                            (D) 19%, 56%
32. When ammonium chloride is gradually and slowly incorporated into an emulsion
    stabilized with ammonium oleate,
    (A)   Emulsion will crack immediately
    (B)   It will invert from o/w to w/o type
    (C)   It will invert from w/o to o/w type
    (D)   There will be no impact on its physical stability
    A prescription requires 4 mEq/ liter of hydrogen phosphate ion HPO4-2. How many
33.
    milligrams of dibasic potassium phosphate K2HPO4 (molecular weight 174) be
    required?
    (A)   174 mg/litre       (B) 30.5 mg/litre     (C) 522 mg / litre (D) 348 mg/ litre
34. Gram positive bacteria typically contain
    (A) cell walls that lack peptidoglycans
    (B) repeating units of arabinogalactan and mycolates in their cell walls
    (C) Peptidoglycan containing muramic acid and D-amino acids in their cell walls
    (D) cell walls containing predominantly polysaccharides and glycoprotein
35. Quaternary structure of a protein molecule refers to
    (A) Specific association of two or more copies of a polypeptide chain to result in
         a biologically active molecule
    (B) Regularly seen local structures within a polypeptide chain
    (C) The portion of the polypeptide chain that comes into contact with another
         protein molecule
     (D) The portion of the structure that gets stabilized upon binding to nucleic acids
36. A blood sample is treated with alkaline phosphotungestic acid to from tungsten
    blue, which is estimated colorimetric ally to give a positive reaction. The sample
    contains
    (A) Protien                                    (B) Serum creatinine
    (C) Serum Phenylalanine                        (D) Uric acid

37. Two important steps for plant regeneration by organogenesis are
                                                    (Q) Initiation of somatic embryogenesis
    (P) Establishment of callus cultures
    (R) Germination of seeds                        (S) Initiation of cell suspensions
    (A) Q, S                  (B) P, R              (C) P, S              (D) Q, R
38. Two tests for ephedrine are
    (P) A solution in dilute HCl, treated with copper sulphate and sodium hydroxide
         gives a violet colour
    (Q) An alcoholic solution gives a red colour with FeCl3
    (R) On shaking with solvent ether, the organic layer shows purple while the
         aqueous layer becomes blue in colour
    (S) A solution of vanillin gives a violet-red colour
    (A) Q, S                  (B) P, S              (C) P, R              (D) Q, R
39. Dried fruits of sweet fennel has two of the following properties
    (P) 80% of E-anethole, 10% of methyl chavicol and 5% (+) – fenchone as
         constitutents
    (Q) 65-75% (+)- Linalool as a constitutent
    (R) The fruit is a diakene, almost cylindrical and surrounded by large stylopod
    (S) The fruit is elongated and surrounded by calyculus
    (A) P, R                  (B) Q, S              (C) P, S              (D) Q, R
40. Dihydroxy acetone phosphate is involved in the biosyntheses of two of the
    following
    P: serotonin              Q: triacylglycerol    R:  pyruvate          S: methionine
    (A) P, Q                  (B) P, R              (C) Q, S              (D) Q, R
41. The virus responsible for SARS can be described by two of the following features
    P:   It contains double-stranded DNA and requires two complementary strands to
         be synthesized to serve as mRNA
    Q: It has distinctive club-shaped particles projecting from the surface, appearing
         like a crown.
    R:   It contains plus-strand RNA that can serve directly as mRNA
    S:   It is retrovirus and requires extra cellular DNA for replication
    (A) P, Q                  (B) P, S              (C) Q, R              (D) R, S
    Two of the following facts are associated with Ethylene oxide gas
42.
           It is non toxic and non inflammable and used for sterilization
    (P)
    (Q)    It is a colourless inflammable gas, toxic in nature and used for sterilization
    (R)    It is diluted with CO2
    (S)    It cannot penetrate plastic and paper packaging
    (A)    P, R               (B) P, S              (C) R, S              (D) Q, R
44. Tranexamic acid is
    P   trans-4-amino methyl cyclohexane carboxylic acid
    Q   a polypeptide
    R   an inhibitor pf proteolytic enzymes including plasmin
    S   used for the prophylaxis of hemorrhage associated with excessive fibrinolysis
    (A) P, S               (B) P, R              (C) Q, R           (D) R, S
45. Prostaglandins are derivatives of
    P   C25 acid
    Q   7-(2 cyclohexyl) pentenoic acid
    R   C20 prostanoic acid
    S   7-(2 octyl cyclopentyl) heptanoic acid
    (A) P, Q               (B) R, S              (C) P, R           (D) Q, S
46. Two ex-officio members of the Drugs Technical Advisory Board under Drugs and
    Cosmetics Act are
    (P)  The Drugs Controller General of India
    (Q)  The President, Medical Council of India
    (R)  The Secretary, Pharmacy Council of India
    (S)  The Director, National Institute of Pharmaceutical Education and Research,
         India
    (A)  P, Q              (B) P, R              (C) R, S           (D) P, S
47. Calfactant is
    P   a sterile non-pyrogenic lung surfactant intended for intracgeal instillation to
        premature infants
    Q   a synthetic surfactant popularly used to prepare total parental nutrition
    R   a potent chelating agent used to prevent metal induced oxidation process
    S   an extract of natural surfactant from calf lungs
    (A) P, Q               (B) R, S              (C) P, S           (D) Q, R

48. In cross-over bioavailability studies, in which the subjects must be rested for
    sufficient time between each drug administration to ensure that 'washout' is
    complete. Practically, wash-out is deemed complete, when
    (P)   95% is washed out                       (Q) 100% is washed out
    (R)   5 biological half-lives have elapsed    (S) 2 biological half-lives have elapsed
    (A)   P, R              (B) P, S              (C) Q, R              (D) Q, S
49. Two reference electrodes are
    P.    Glass membrane electrodes               Q.  Sb/Sb2O3 electrodes
    R.    Calomel electrode                       S.  Silver/Silver-chloride electrode
    (A)   P, Q              (B) Q, S              (C) R, S              (D) P, R
50. Polarography can be used for the
    P     simultaneous determination of several analytes
    Q     study of resistance of a solution
    R     study of current potential relationship
    S     study of optical activity of organic compounds
    (A)   P, S              (B) Q, S              (C) P, R              (D) P, Q
51. Primary amines show
          Two N-H stretching bands in the range of 3500 – 3300cm-1
    P
          Only one band in the region 3500 – 3300 cm-1
    Q
    R     -NH band in primary amine results in a broad band in the region 1640 –
          1560 cm-1
          the typical –NH2 stretching value at 1715 cm-1
    S
    (A)   Q, R              (B) P, R              (C) P, S              (D) Q, S
52. The drug disulfiram is
         known to inhibit dopamine β-hydroxylase and cause noradrenaline depletion
    P
    Q    a substance that produces aversive reaction to alcohol
         known to stimulate dopamine β-hydroxylase
    R
    S    used in barbiturate poisoning
    (A) P, S                (B) Q, R              (C) R, S              (D) P, Q
53. Two important attributes associated with L- asparaginase
    P:   an enzyme obtained from E.Coli and is administered paranterally
    Q: an enzyme obtained from Streptococcus caespitosus and is administered
         orally
    R:   used in acute lymphocytic leukemia
    S:   used as fibrinolytic
    (A) P, S                (B) P, R              (C) Q, R              (D) Q, S

54. Amikacin is
    P   a semisynthetic aminoglycoside and a derivative of kanamycin
    Q   a semisynthetic aminoglycoside and a derivative of tobramycin
    R   it is administered parenterally and does not cause nephrotoxicity and
        otooxicity
    S   it is administered parenterally and is both nephrotoxic and ototoxic
    (A) P, Q               (B) P, R                (C) P, S             (D) Q, S
55. Matching exercises. Match Group I and Group-II and identify the correct
    combinations
        Group-I                                         Group-II
        Plant                                           Source
    (P) Thorn apple                                (1) Dried leaves and flowering
                                                        tops of Hyoscyamus niger
    (Q) Henbane                                    (2) Dried leaves and flowering
                                                        tops of Datura Stramonium
    (R) Deadly nightshade                          (3) Leaves of Digitalis purpurea dried
                                                        at a temperature below 60oC
    (S) Foxglove leaves                            (4) Dried leaves and other aerial
                                                        parts of Atropa acuminate
    (A) P - 2 Q - 1 R - 4 S - 3                    (B) P - 1 Q - 2 R - 3 S - 4
    (C) P - 3 Q - 4 R - 2 S - 1                    (D) P - 2 Q - 3 R - 4 S - 1
56. Group I                Group II
    Drugs                  Source
    (P)   Kaolin           (1) natural diatomaceous earth consisting of
                                siliceous skeletons of fossils
    (Q)   Kieselguhr       (2) purified native hydrated aluminium silicate free
                                from gritty particles
    (R)   Calamine         (3) hydrated magnesium silicate
    (S)   Talc             (4) an ore contains zinc oxide with a small amount
                                of ferric oxide
          P −1 Q − 4 R −3 S −2                     (B) P − 2 Q − 4 R − 1 S − 3
    (A)
          P −2 Q −1 R − 4 S − 3                    (D) P − 3 Q − 2 R − 1 S − 4
    (C)
57. Proof for the following in the natural products is obtained by some reactions
        Group-I                                         Group-II
        Natural product                                 Reactions
    (P) Cholesterol-nature of ring                 (1) Treatment with HNO2 forms a
                                                        nitroso compound
                                                   (2) Selenium dehydrogenation gives
    (Q) Ephedrine-secondary amino group
                                                        Diel's hydrocarbon

    (R) Morphine-secondary-OH group               (3) With-CH3l in aqueous KOH gives
                                                       (-) codeine, which is not soluble
                                                       in alkali; codeine can be oxidized
                                                       with chromic acid to codeinone
    (S) Caffeine-nature of ring                   (4) Oxidation with potassium
                                                       chlorate in hydrochloric acid
                                                       gives dimethyl alloxan and
                                                       methyl urea
    (A) P - 3 Q - 1 R - 2 S - 4                   (B) P - 2 Q - 1 R - 3 S - 4
    (C) P - 3 Q - 4 R - 1 S - 2                   (D) P - 4 Q - 2 R - 1 S - 3
58. Derivatives of cortisol and their structural modifications are
        Group I                 Group II
        Derivative              Structural modification
    P.  Prednisolone        1.  1, 2-dehydro, 9α-fluoro, 16α-methyl
    Q.  Dexamethasone 2.        1, 2-dehydro
    R.  Betamethasone       3.  1, 2- dehydro, 9α-fluoro, 16β-methyl
    S.  Triamcinolone       4.  1, 2-dehydro, 9α-fluoro, 16α-hydroxy
    (A) P-2 Q-1 R-3 S-4                           (B) P-2 Q-1 R-3 S-4
    (C) P-2 Q-4 R-3 S-1                           (D) P-3 Q-2 R-1 S-4
59.     Group I                 Group II
        Drugs                   Starting material for synthesis
    P.  Clofazimine         1.  p-chloronitro benzene
    Q.  Ketoconazole        2.  L-phenyl alanine
    R.  Melphalan           3.  -N-(4-chlorophenyl)-O-phenylenediamine
    S.  Dapsone             4.  2, 4-dichloro phenylbromide and glycerine
    (A) P-1 Q-2 R-3 S-4                           (B) P-4 Q-3 R-1 S-2
    (C) P-3 Q-4 R-2 S-1                           (D) P-2 Q-1 R-4 S-3
60. Group I                                       Group II
    Industrial dryers                             Pharmaceutical materials dried
    (P)  Drum dryer                               (1) Antibiotic solution
    (Q)  Fluidized bed dryer                      (2) Tablet granules
    (R)  Spray dryer                              (3) Gelatin
    (S)  Freeze dryer                             (4) Suspension of kaolin
         P −1 Q −3 R − 4 S −2                     (B) P − 4 Q − 2 R − 3 S − 1
    (A)
         P − 4 Q −2 R −1 S −3                     (D) P − 3 Q − 2 R − 4 S − 1
    (C)

61.   Group I                                     Group II
      Name of equation                            Equation
                                                        dM DS
                                                                   (Cs − C )
                                                            =
      (P)   Noyes & Whitney equation              (1)
                                                        dt      h
                                                                              b −1 P
                                                            P           1
                                                                    =       +
      (Q)   B.E.T equation                        (2)
                                                        Y (P0 − P ) Ymb Ymb P0
                                                            d2 (Ps − P0 ) g
                                                  (3) v =
      (R)   Stokes equation
                                                                18η0
                                                                DCs t
                                                                        . (2A − Cs )
                                                  (4) Q =
      (S)  Higuchi equation
                                                              2A − Cs
            P − 4 Q −2 R − 3 S −1                 (B) P − 2 Q − 4 R − 1 S − 3
      (A)
            P − 4 Q −2 R −1 S −3                  (D) P − 1 Q − 2 R − 3 S − 4
      (C)
62.   Group I                Group II
      Types of coating       Coating materials
      (P)   Seal coating     (1) HPMC
      (Q)   Sub coating      (2) Carnauba wax
      (R)   Polishing        (3) Gelatin
      (S)   Film coating     (4) PEG 4000
            P − 4 Q −3 R −2 S −1                  (B) P − 4 Q − 2 R − 3 S − 1
      (A)
            P −2 Q − 4 R −1 S −3                  (D) P − 1 Q − 3 R − 2 S − 4
      (C)
63.
                    Group I                                   Group II
              Interacting drugs                     Pharmacological effect
    P   Verapamil and Atenolol           1 Increased risk of hyperkalemia
    Q   Clozapine and Co-trimoxazole     2 Bradycardia and asystole
    R   Alcohol and Flunitrazepam        3 Increased risk of bone marrow suppression
    S   Ramipril and Amiloride           4 Severe CNS depression
      (A) P − 4 Q − 2 R − 3 S − 1                 (B) P − 2 Q − 3 R − 4 S − 1
      (C) P − 3 Q − 4 R − 2 S − 1                 (D) P − 4 Q − 1 R − 2 S − 3
64.
                                Group I                      Group II
                               Receptors                     Agonists
                     β-adrenetgic (Type 2)
                 P                                    1   Phenylephrine
                     α-adrenergic (Type 1)
                 Q                                    2   Bromocriptine
                 R   Dopaminergic (Type 2)            3   Ritodrine
                 S   5-hydroxytryptamine (Type 1A)    4   Buspirone
      (A) P − 1 Q − 4 R − 3 S − 2                 (B) P − 3 Q − 2 R − 4 S − 1
      (C) P − 2 Q − 3 R − 4 S − 1                 (D) P − 3 Q − 1 R − 2 S − 4

65.
                Group I                          Group II
                 Drugs                         Mechanism
           P  Terbinafine  1   Inhibition of reverse transcriptase
           Q  Cidofovir    2   Selective inhibition of squalene epoxidase
           R  Imatinib     3   Inhibition of DNA polymerase
           S  Stavudine    4   Tyrosine kinase inhibitor
    (A) P − 1 Q − 1 R − 3 S − 4                   (B) P − 4 Q − 3 R − 2 S − 1
    (C) P − 2 Q − 3 R − 4 S − 1                   (D) P − 3 Q − 2 R − 1 S − 4
66.     Group I                                       Group II
        Materials used                                Instrumental techniques
    P.  Sodium chloride                           1.  Colorimetry
    Q.  Glass                                     2.  UV spectrophotometry
    R.  Quartz                                    3.  X-ray diffraction
    S.  Potassium hydrogen phthalate              4.  IR spectrophotometry
                                                  (B) P-4 Q-1 R-2 S-3
    (A) P-1 Q-2 R-3 S-4
    (C) P-3 Q-4 R-1 S-2                           (D) P-2 Q-3 R-4 S-1
67.     Group I                          Group II
        Drugs                            B. P. Assay
    P.  Iopanoic acid                1. Titration of a solution in anhydrous formic
                                         Acid and acetic anhydride with 0.1 N
                                         perchloric acid
    Q.  Cyclizine hydrochloride      2. Titration of a solution in dimethyl formamide
                                         With 0.1 M tetrabutyl ammonium hydroxide
    R.  Chlorothiazide               3. Treating with sodium hydroxide and zinc
                                         powder and then titration with 9.1 N silver
                                         nitrate
    S.  Chlorambucil                 4. Titration with 0.1 N sodium hydroxide using
                                         phenolphthalein indicator
    (A) P-1 Q-2 R-3 S-4                           (B) P-2 Q-4 R-1 S-3
    (C) P-4 Q-3 R-1 S-2                           (D) P-3 Q-1 R-2 S-4
68.     Group I                          Group II
        Techniques                       Related equations
                                          id=708nCD1/2m2 / 3 t1 / 6
    P.  Potentiometry                1.
                                          VR = tRFc
    Q.  Polarography                 2.

                                                                         RT
                                                                            log H+ 
                                            P-3 Q-1 R-2 S-4E=E0 −
     R.   Colorimetry                   3.                                       
                                                                         nF
                                             A=εbc
     S.   Column chromatography         4.
     (A) P-1 Q-4 R-3 S-2                            (B) P-3 Q-2 R-1 S-4
     (C) P-2 Q-3 R-4 S-1                            (D) P-3 Q-1 R-4 S-2
69.
                  Group I                                        Group II
                    Test                                         Principle
     P   Direct agglutination test    1   Measures antibody titres after soluble antigens
                                          are attached to inert particles and incubated with
                                          antibodies
     Q   Passive agglutination        2   Detects blocking-type antibodies, globulins and
                                          complement that are attached to red cell
                                          antigens
     R   Haemagglutination            3   RBCs coated with homologous antigens added to
         inhibition test                  antibodies incubated with soluble antigens
     S   Coomb's test                 4   RBS antigens incubated with antibodies and
                                          antibody titre visually examined
     (A) P − 2 Q − 4 R − 1 S − 3                    (B) P − 4 Q − 1 R − 3 S − 2
     (C) P − 1 Q − 3 R − 2 S − 4                    (D) P − 3 Q − 2 R − 4 S − 1
70.
                Group I                                   Group II
               Enzymes                                   Functions
           +   +
    P   Na -K ATPase              1   Electron transport
    Q   Cytochrome c oxidase      2   Pathway converting pyruvate to oxaloacetate
    R   Malate dehydrogenase      3   Generation of electrochemical potential
    S   Tyrosine Kinase           4   Signal transduction
     (A) P − 3 Q − 1 R − 2 S − 4                    (B) P − 1 Q − 3 R − 4 S − 2
     (C) P − 2 Q − 4 R − 1 S − 3                    (D) P − 4 Q − 2 R − 3 S − 1
                        Common Data Questions 71, 72 & 73
                                                          H
                                                          N      CH3
                                                H3C
                           O
                     H
                                NO2 + NH3 → H3COOC               COOCH3
               X +
                                                                 NO2
                                                      Nifedipine


71.  Reagent X is
                                      H2
                                                                                   O
                                                                 NH2        H3C
                                                        H3C
                                       C
               H3C    O
     (A)                     (B) H3C                (C)                (D)
                                          CH2
                                                                                CH2
                                                             CH2
                                          |
                   CH2                                                      H2N
                                                        H3C
                                          CH2
          CH3OOC                 CH3OOC
72.  Nifedipine when exposed to day light and artificial light, is readily converted to a
     derivative of
     (A) 4-Phenyl pyridine                          (B) Nitrosophenyl pyridine
     (C) Diazophenyl pyridine                       (D) Nitrobenzene
73.  The B.P.assay of Nifedipine is by titration of a
     (A) Solution in anhydrous acetic acid with 0.1M perchloric acid
     (B) Solution in previously neutralized acetone with 0.1N sodium hydroxide; end
           point by potentiometry
     (C) Solution in previously neutralized acetone against standard potassium
           dichromate solution
     (D) A solution in 2 methyl -2 propanol and perchloric acid with 0.1M cerium
           sulphate using ferroin as indicator
                         Common Data Questions 74 & 75
    Tenoposide is a natural product used for the management of certain diseases.
74.  It is derived form
     (A) Flavonolignans form Silybum marianum
     (B) Lignans from Podophyllum peltatum
     (C) Lignans from Schizandra chinensis
     (D) Neolignans from Piper futokadsura
75.  This drug is used in the management of
     (A) Candidiasis                                (B) Trypanosomiasis
     (C) Cardiac arrhythmia                         (D) Acute leukemia in children
         Linked Answer Questions: Q.76 to Q.85 Carry Two Marks Each
                 Statement for Linked Answer Questions: 76 & 77
     Extracts of Chondrodendron tomentosum, family menispermaceae contains
     several alkaloids
76.  One of the important alkaloid is
     (A) (-) Phyllandrene                           (B) (+) Holarrhenine
     (C) (+) Tubocurarine                           (D) (±) Colchicine


77. This alkaloid has
    (A) Bis benzyl tetrahydro isoquinoline ring (B) Quinoline ring
    (C) Phenanthrene ring                       (D) Pyrido pyrimidine ring
                 Statement for Linked Answer Questions: 78 & 79
    Several drugs are used for migraine
78. Acute migraine is treated with
    (A) Prazosin            (B) Formeterol      (C) Sumatriptan            (D) Dopamine
79. The drug chosen is an agonist of
    (A) α1 adrenoceptor                         (B) α2 adrenoceptor
                                                (D) 5 − HTID receptor
    (C) M3 receptor
                 Statement for Linked Answer Questions: 80 & 81
    A drug which is used for malignant melanoma is obtained as follows
                                     H
                                     N
                              H2N
                                                diazotization
                                               X       →
                                         N
                           H2NOC
80. X is       N+
                                                                       H
               ||
                                                                       N
                                                                H2N
                       N
               N
    (A)                                         (B)
                                                                           N
                         N                                    HOOC
         H2NOC
                         H                                              H
                         N                                              N
                  H2N
    (C)                                         (D)
            N+
                            N                                               N
                  N
                                                              H2NOC
                      O
81. X on treatment with dimethylamine gives the drug
                                                               H3C
                    CH3
                         H                                          N
                    |
    (A)                                         (B)                     N
                         N
                    N                                          H3C
                                                                        ||     H
            H3C
                                                                        N      N
                            N
             H2NOC
                                                                                  N
                                                                    H2NOC


                                                                          H
                                H
                           H                                       H2N
      (C)                                          (D)                    N
                 H3C            N
                           N
                      N
                       |
                                                                              N
                      CH3    N      N                            N
                      H2NOC
                                                                       O
                                                              N
                                                          H3C    CH3
                  Statement for Linked Answer Questions: 82 & 83
      A 250 mg dose of a drug was administered to a patient by rapid IV injection. The
      initial plasma concentration was 2.50μg/mL. After 4 hours, the plasma
      concentration was 1.89μg/mL. Assuming that the drug was eliminated by a
      pseudo first order process and the body behaves as one compartment model
82.   Kel is
             0.0699 h−1        (B) 0.0349 h−1      (C) 1.623h−1        (D) 0.699 h−1
      (A)
83  Biological half life is
      (A)    4.95 hours        (B) 19.82 hours     (C) 99.1 hours      (D) 9.91 hours
                  Statement for Linked Answer Questions: 84 & 85
      As per the Woodward-Fieser rule, the absorption maxima of the compound shown
      is calculated from the base value and the ring residue values
84.   Base value is
      (A) 215nm                (B) 253nm           (C) 240nm           (D) 217nm
85.   Absorption maxima is
      (A) 273nm                (B) 258nm           (C) 265nm           (D)237nm