Gate Syllabus for Pharmaceutical Science
Natural Products: Pharmacognosy & Phytochemistry – Chemistry, tests,
isolation, characterization and estimation of phytopharmaceuticals belonging to
the group of Alkaloids, Glycosides, Terpenoids, Steroids, Bioflavanoids,
Purines, Guggul lipids. Pharmacognosy of crude drugs that contain the above
constituents. Standardization of raw materials and herbal products. WHO
guidelines. Quantitative microscopy including modern techniques used for
evaluation. Biotechnological principles and techniques for plant development,
Tissue culture.
Pharmacology: General pharmacological principles including Toxicology. Drug
interaction. Pharmacology of drugs acting on Central nervous system,
Cardiovascular system, Autonomic nervous system, Gastro intestinal system and
Respiratory system. Pharmacology of Autocoids, Hormones, Hormone antagonists,
chemotherapeutic agents including anticancer drugs. Bioassays, Immuno
Pharmacology. Drugs acting on the blood & blood forming organs. Drugs acting on
the renal system.
Medicinal Chemistry: Structure, nomenclature, classification, synthesis, SAR
and metabolism of the following category of drugs, which are official in Indian
Pharmacopoeia and British Pharmacopoeia. Introduction to drug design.
Stereochemistry of drug molecules. Hypnotics and Sedatives, Analgesics, NSAIDS,
Neuroleptics, Antidepressants, Anxiolytics, Anticonvulsants, Antihistaminics,
Local Anaesthetics, Cardio Vascular drugs – Antianginal agents Vasodilators,
Adrenergic & Cholinergic drugs, Cardiotonic agents, Diuretics, Antijypertensive
drugs, Hypoglycemic agents, Antilipedmic agents, Coagulants, Anticoagulants,
Antiplatelet agents. Chemotherapeutic agents – Antibiotics, Antibacterials,
Sulphadrugs. Antiproliozoal drugs, Antiviral, Antitubercular, Antimalarial,
Anticancer, Antiamoebic drugs. Diagnostic agents. Preparation and storage and
uses of official Radiopharmaceuticals, Vitamins and Hormones. Eicosonoids and
their application.
Pharmaceutics : Development, manufacturing standards Q.C. limits, labeling,
as per the pharmacopoeal requirements. Storage of different dosage forms and new
drug delivery systems. Biopharmaceutics and Pharmacokinetics and their
importance in formulation. Formulation and preparation of cosmetics – lipstick,
shampoo, creams, nail preparations and dentifrices. Pharmaceutical calculations.
Pharmaceutical Jurisprudence: Drugs and cosmetics Act and rules with respect
to manufacture, sales and storage. Pharmacy Act. Pharmaceutical ethics.
Pharmaceutical Analysis: Principles, instrumentation and applications of the
following: Absorption spectroscopy (UV, visible & IR). Fluorimetry, Flame
photometry, Potentiometry. Conductometry and Plarography. Pharmacopoeial assays.
Principles of NMR, ESR, Mass spectroscopy. X-ray diffraction analysis and
different chromatographic methods.
Biochemistry. Biochemical role of hormones, Vitamins, Enzymes, Nucleic acids,
Bioenergetics. General principles of immunology. Immunological. Metabolism of
carbohydrate, lipids, proteins. Methods to determine, kidney & liver function.
Lipid profiles.
Microbiology : Principles and methods of microbio0logical assays of the
Pharmacopoeia. Methods of preparation of official sera and vaccines. Serological
and diagnostics tests. Applications of microorganisms in Bio Conversions and in
Pharmaceutical industry.
Clinical Pharmacy : Therapeutic Drug Monitoring Dosage regimen in Pregnancy
and Lactation, Pediatrics and Geriatrics. Renal and hepatic impairment. Drug –
Drug interactions and Drug – food interactions, Adverse Drug reactions.
Medication History, interview and Patient counseling.
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